Circulating eosinophil progenitors express major trafficking related molecules and are more activated compared to mature eosinophils in patients with asthma
نویسندگان
چکیده
Background Eosinophilic inflammation represents a hallmark for allergic asthma. Eosinophils differentiate in the bone marrow from CD34+ cells and are released into the blood and traffic to the lung tissue. To date, the majority of studies originate from animal models or from humans after allergen exposure. Thus, it is unclear if mature eosinophils and eosinophil progenitors express similar levels of trafficking related molecules. Therefore, we characterized the expression of trafficking related molecules on circulating eosinophil progenitors in patients with stable asthma.
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